Research finds Pear’s reSET-O might decrease prices of treating opioid use dysfunction

Pear Therapeutics reSET-O, a prescription app for treating opioid use dysfunction, could decrease sufferers’ well being care prices, in contrast with sufferers who don’t use the app, in line with a research printed within the journal Hospital Follow.

“Engagement and continued therapy with reSET-O in sufferers with OUD handled with buprenorphine is related to substantial real-world reductions in medical prices within the 6-month interval following the initiation of the reSET-O prescription,” wrote the research’s authors.

The research was funded by Pear, and its authors are employed by or paid to seek the advice of for the corporate.


Researchers discovered sufferers who used reSET-O together with buprenorphine and counseling lowered their well being care prices by $2,385 per individual within the six months after they began utilizing the app, in contrast with the six months earlier than. Sufferers who solely accessed buprenorphine and counseling noticed a $353.80 rise in prices the six months after they started therapy.

The price of the prescription therapeutic was $1,665 for every consumer, leaving a price financial savings of $720 per affected person.


The research analyzed real-world healthcare-resource utilization and related prices from 351 individuals who had been prescribed the reSET-O app between October 2018 and October 2019. The 321 sufferers who used a single 84-day course noticed value reductions, whereas the 30 customers who weren’t engaged with the app after week one skilled a rise in prices within the six months after therapy started.

reSET-O, the primary prescription digital remedy approved by the Meals and Drug Administration to deal with opioid-use dysfunction, makes use of a collection of 67 on-demand audio, textual content and video “remedy classes” which can be designed to maintain sufferers engaged in outpatient therapy.


Drug overdose deaths soared in the course of the COVID-19 pandemic, with the Nationwide Heart for Well being Statistics predicting greater than 93,000 deaths in 2020. That represents a big soar from the yr earlier than. In 2019, the NCHS predicted simply over 72,000 deaths. 

The Facilities for Illness Management and Prevention attributes a lot of these drug overdose deaths to opioids. In 2019, opioids had been concerned in about 71% of deaths.

In the meantime, the pandemic made it tougher for some to entry healthcare as sufferers averted in-person visits and shifted to telehealth, a platform that some sufferers might discover tougher to make use of.

“Prescribed by physicians, reSET-O can safely broaden use of the behavioral part of therapy by giving sufferers 24/7 entry to therapeutic content material,” Dr. Yuri Maricich, Pear’s chief medical officer, mentioned in an announcement.

“This will likely assist deal with the problems of restricted entry to clinicians, both due to geographical variations, lack of viable appointment time slots for particular person sufferers, or because of restrictions on face-to-face interactions because of the COVID-19 pandemic.”

In one other research funded by the corporate and printed within the Professional Assessment of Pharmacoeconomics & Outcomes Analysis, the authors discovered reSET-O contributed to a web value discount of $2,150 per affected person. Pear’s different digital therapeutic merchandise have had combined success in research. 

Pear’s app for power insomnia, Somryst, has been proven to lower the period of time it took customers to go to sleep, lowered the period of time they spent awake at night time and lowered insomnia severity.

However a Novartis scientific trial for Pear’s app to deal with schizophrenia discovered no distinction between sufferers who used the app or a placebo, which the corporate’s CEO chalked as much as “methodological points” with the research.

“I’d like to finish by conveying what’s a cautious optimism round digital therapeutics for schizophrenia,” Pear CEO Corey McCann informed MobiHealthNews in January. “As you most likely know, this has been an extremely troublesome inhabitants for typical therapeutics.

“There’s a complete historical past of scientific trial failures within the drug world, and I feel we’ve seen the start of some very fascinating efficacy indicators with digital therapeutics for this affected person inhabitants, and we’ll proceed to push that ahead.”

Pear lately went public through a $1.6 billion particular function acquisition firm (SPAC) merger with Thimble Level Acquisition Corp. On the time of the announcement, the corporate mentioned it might use the brand new funds in its efforts to develop its commercialization efforts for its FDA-cleared merchandise and assist it proceed to analysis new merchandise.

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